Work

Alternative RNA splicing and cancer

Year: 2013

Type: review

Abstract: Alternative splicing of pre‐messenger RNA ( mRNA ) is a fundamental mechanism by which a gene can give rise to multiple distinct mRNA transcripts, yielding protein isoforms with different, even opposing, functions. With the recognition that alternative splicing occurs in nearly all human genes, its relationship with cancer‐associated pathways has emerged as a rapidly growing field. In this review, we summarize recent findings that have implicated the critical role of alternative splicing in cancer and discuss current understandings of the mechanisms underlying dysregulated alternative splicing in cancer cells. WIREs RNA 2013, 4:547–566. doi: 10.1002/wrna.1178 This article is categorized under: RNA Processing > Splicing Regulation/Alternative Splicing RNA in Disease and Development > RNA in Disease

Source: Wiley Interdisciplinary Reviews - RNA

DOI: 10.1002/wrna.1178

Authors: Sali Liu, Chonghui Cheng

Institutions: Northwestern University, Robert H. Lurie Comprehensive Cancer Center of Northwestern University

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Defense, American Association for Cancer Research, American Cancer Society, National Cancer Institute