Work

Development of novel echogenic-imageable thermosensitive liposome for optimizing tumor drug distribution using ultrasound guided HIFU

Year: 2015

Type: article

Abstract: Background/introductionA major challenge in HIFU mediated Image Guided Drug Delivery (IGDD) is developing accurate means to implement real-time drug delivery control, and to optimize intratumoral drug distribution.To facilitate clinical translation, objectives of this study were to: 1) develop echogenic E-LTSL, a low temperature sensitive liposome co-loaded with an US contrast agent (Perfluoropentane, PFP) and doxorubicin, 2) determine stability of contrast agent encapsulation and characterize doxorubicin release from E-LTSL and 3) investigate the ability of E-LTSL to report on realtime doxorubicin distribution with Ultrasound (US)-guided hyperthermia. MethodsE-LTSL was loaded passively with PFP using an innovative 1-step sonoporation method and actively loaded with doxorubicin.Doxorubicin release and PFP imageability from E-LTSL in phantoms was quantified by fluorescence spectroscopy, ultrasound imaging and transmission electron microscopy (TEM) in combination with mild hyperthermia (40-42°C).Ultrasound imageability of E-LTSL was determined in vivo in a mouse xenograft model of human prostate cancer.

Source: Journal of Therapeutic Ultrasound

DOI: 10.1186/2050-5736-3-s1-p73

Authors: Ashish Ranjan, Danny Maples, Ryan Newhardt, Venkatesan Perumal

Institution: Oklahoma State University

Language: English

Topic: Ultrasound and Hyperthermia Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Oklahoma Center for the Advancement of Science and Technology, National Institutes of Health, National Cancer Institute