Work

Conformation Takes Precedence over Sequence in Adeno-Associated Virus DNA Replication

Year: 1984

Type: article

Abstract: Deletion of an 11-base symmetrical sequence in the inverted terminal repetition of the adeno-associated virus 2 genome inhibits DNA replication. Substitution of either an 8- or a 12-base symmetrical sequence unrelated to the original 11-base sequence restores DNA replication.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.4.7.1416

Authors: R B Lefebvre, S Riva, K I Berns

Institutions: University of Florida, Istituto di Genetica Molecolare, National Research Council

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institutes of Health

OpenAlex ID: W1933041610

FWCI: 1.457

Cites: 17

Cited by: 59

Related to: 10