Work

Structure of the Rat α1-Acid Glycoprotein Gene

Year: 1985

Type: article

Abstract: The complete nucleotide sequence of the rat alpha 1-acid glycoprotein gene has been determined from an isolated lambda recombinant bacteriophage. Southern blot analysis and DNA sequencing indicate that there is only one gene per genome; it contains six exons and is located within a 3,200-base-pair fragment starting from a TATA box and extending to the polyadenylation signal AATAAA. Transcription starts 37 base pairs upstream from the beginning of the translation codon ATG. The TATA box (TATAAA) lies 26 base pairs upstream from this site. The gene contains several potential glucocorticoid receptor-binding sites, both inside and outside the structural gene.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.5.12.3634-3639.1985

Authors: Yu-Cheng J. Liao, John M. Taylor, James L. Vannice, Gary A. Clawson, Edward A. Smuckler

Institutions: University of California, San Francisco, San Francisco General Hospital, Genentech

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Cancer Institute

Award: G8052816122