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Brain‐derived neurotrophic factor interacts with adult‐born immature cells in the dentate gyrus during consolidation of overlapping memories

Year: 2014
Type: article
Abstract: Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. The computational process for making representations of similar input patterns more distinct from each other has been referred to as "pattern separation." Although adult-born immature neurons have been implicated in this memory feature, the precise role of these neurons and associated molecules in the processing of overlapping memories is unknown. Recently, we found that brain-derived neurotrophic factor (BDNF) in the dentate gyrus is required for the encoding/consolidation of overlapping memories. In this study, we provide evidence that consolidation of these "pattern-separated" memories requires the action of BDNF on immature neurons specifically.
Source: Hippocampus
DOI: 10.1002/hipo.22304
Authors: Pedro Bekinschtein, Brianne A. Kent, Charlotte A. Oomen, Gregory D. Clemenson, Fred H. Gage, Lisa M. Saksida, Timothy J. Bussey
Language: English
Open Access status: hybrid
Estimated APC paid: $2,863
Funders: James S. McDonnell Foundation, European Commission, Directorate for Biological Sciences, Biotechnology and Biological Sciences Research Council, National Institute on Aging, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke
Awards: G3207356259, G393177772, G5702163051, Plasticity-related mechanisms involved in memory and pattern separation in the medial temporal lobe, G6285100446, Novel Methods leading to New Medications in Depression and Schizophrenia
OpenAlex ID: W1934269805
FWCI: 4.291
Cites: 32
Cited by: 94
Related to: 10