Detection and characterization of DNA-anti-DNA complexes in a patient with systemic lupus erythematosus.
Year: 1977
Type: article
Study design: Case Report
Abstract: DNase digestion of SLE serum, with consequent release of bound DNA antibody has been proposed as a method for the direct demonstration of circulating DNA-anti-DNA complexes. In the present studies on the serum of a girl with active SLE nephritis, circulating DNA-anti-DNA complexes were demonstrated at the precise time of relapse of SLE nephritis. Ultracentrifugation showed that these complexes were of low molecular weight.
Source: PubMed
Authors: C D Bruneau, J P Edmonds, G R Hughes, L Aarden
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W193497315