Review Article and Clinical Experience: EMERGING MULTIPLE PROPERTIES OF HIGH DOSE THIAMINE AND B6-B12 VITAMINS Therapeutic Possibilities for Diabetic Vascular Complications
Year: 2009
Type: article
Abstract: High prevalence of low plasma thiamine level in diabetes (T1DM and T2DM) linked to a marker of vascular disease. The deficiency of thiamine in diabetes increases the susceptibility of vascular cells to the injurious effects of hyperglycemia (“PAHA” and “PAHAM”), and hence increased the risk of developing microvascular complications. Thiamine supplementation to high dose as adjunct therapy may prevent the development of vascular complications in clinical diabetes, also may result in the reversal of diabetic dyslipidemia. One of the most important function of B6 Vit is to suppress the activation and translocation of NFkB. The combination of B12 Vit and folate show the protective effects on the developments of myocardial infarction and stroke. In conclusion, the FDC drug Neurobion® show several therapeutic possibilities with multiple clinical benefits for patients with diabetes mellitus. Thiamine repletion with thamine or benfotiamine may prevent or delay the development of diabetic microvascular complications in vivo.
Source: Folia Medica Indonesiana
Author: Askandar Tjokroprawiro
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $98
OpenAlex ID: W1935001823