Work

Cardiopoietic Index Predicts Heart Repair Fitness of Patient-Derived Stem Cells

Year: 2015

Type: article

Abstract: BACKGROUND: Stem cell therapy shows promise for regeneration in heart disease, yet interpatient variability challenges implementation into practice. AIM: To establish a biomarker profile, predictive of reparative potential in patient-derived progenitors, human mesenchymal stem cells were isolated from patients undergoing coronary artery bypass grafting. MATERIALS & METHODS: Stem cell delivery postinfarction translated into divergent benefit, distinguishing reparative from nonreparative populations. RESULTS: While the nonreparative subtype was characterized by low expression of cardiac transcription factors, reparative human mesenchymal stem cells demonstrated high expression of cardiac transcription factors. CONCLUSION: This index of factors (cardiopoietic index) was found sensitive and specific in predicting impact of stem cell benefit on left ventricular function. The cardiopoietic index thus offers a tool to screen stem cell fitness for heart repair prior to intervention.

Source: Biomarkers in Medicine

DOI: 10.2217/bmm.15.31