Year: 1993
Type: article
Abstract: Abstrac t.In chronical1y prcpared guinea pigs, wc invesligatcd the time course of botulinum toxin A's (Bot A) effecl on the blink reflex by monitoring lid movements and EMG activi lY prior 10 and after Bol A injection iolO the orbicu laris oculj muselc (OOemg), o r after nerve erush of the zygomatie nerve.We correlated these alteratiolls with tbe morphologieal changcs of the orbicula ris oculi (Ud-dosillg) museIes of the same animals.After Bot A treatment there was a profound reduction of OOemg activity and blink amplitudes as weil as a slowing ofmaximum bljnk down-phase velocity.Blink up-phases, howcver, remained unchanged.G radual recovery of OOemg magnitude and blink amplitude started around day 6; a
Authors: Anja K. E. Horn, John D. Porter, Craig Evinger
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1937591820