Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect.
Year: 2006
Type: article
Abstract: We were interested to read the article of Asakawa et al ( Gut 2005; 54 :18–24) which reported that intracerebroventricular and peripheral administration of desacylated ghrelin inhibited food intake in mice in the fasted state. Acylated ghrelin (AG) has a unique biological structure with an acyl side chain on the third amino acid residue. AG is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R1a)1 and stimulates feeding and growth hormone release. In contrast, desacylated ghrelin (DAG), which does not have the acyl side chain, has no affinity for the GHS-R1a.1 As the authors …
Source: PubMed Central
Authors: N M Neary, M R Druce, C J Small, S R Bloom
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1939271022