Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals

Year: 2015

Type: article

Abstract: We evaluated the impact of antiretroviral-induced dyslipidemia on hepatitis C virus (HCV) biogenesis in human immunodeficiency virus (HIV)/HCV coinfected patients. This study used serum samples from antiretroviral-naive HIV/HCV patients initiating their first regimen as part of AIDS Clinical Trials Group study protocols (A5142, A5202). Initiation of antiretrovirals increased most lipoproteins and apolipoproteins. In the multivariable model, changes in apolipoproteins were associated with changes in log10 HCV RNA from baseline to week-24 of therapy. Off-target lipogenic changes need to be considered in the context of liver and other metabolic disease in HIV/HCV patients.

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofv066

Authors: Susanna Naggie, Keyur Patel, Lan-Yan Yang, Shein-Chung Chow, Victoria Johnson, John R. Guyton, Andrew J. Muir, Mark Sulkowski, Charles Hicks

Institutions: Duke University, Duke Medical Center, Chang Gung Memorial Hospital, Taoyuan Chang Gung Memorial Hospital, Linkou Chang Gung Memorial Hospital, University of Alabama, University of Alabama at Birmingham, Birmingham VA Medical Center, Johns Hopkins University, University of California San Diego

Language: English

Topic: Hepatitis C virus research

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,053

Funders: Harvard T.H. Chan School of Public Health, National Institutes of Health, Center for AIDS Research, Duke University, Center for AIDS Research, University of Washington, National Institute on Drug Abuse, National Institute of Allergy and Infectious Diseases

OpenAlex ID: W1939323311