Work

From Saccharomyces cerevisiae to Candida glabrata in a few easy steps: important adaptations for an opportunistic pathogen

Year: 2010

Type: article

Abstract: The opportunistic human fungal pathogen Candida glabrata is closely related to Saccharomyces cerevisiae, yet it has evolved to survive within mammalian hosts. Which traits help C. glabrata to adapt to this different environment? Which specific responses are crucial for its survival in the host? The main differences seem to include an extended repertoire of adhesin genes, high drug resistance, an enhanced ability to sustain prolonged starvation and adaptations of the transcriptional wiring of key stress response genes. Here, we discuss the properties of C. glabrata with a focus on the differences to related fungi.

Source: FEMS Microbiology Letters

DOI: 10.1111/j.1574-6968.2010.02102.x

Authors: Andreas Roetzer, Toni Gabaldón, Christoph Schüller

Institutions: University of Vienna, Max Perutz Labs, Centre for Genomic Regulation

Language: English

Topic: Fungal and yeast genetics research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Austrian Science Fund, Universität Wien, Ministerio de Ciencia e Innovación