Year: 2011
Type: review
Abstract: To cite this article: Maurer M, Bader M, Bas M, Bossi F, Cicardi M, Cugno M, Howarth P, Kaplan A, Kojda G, Leeb‐Lundberg F, Lötvall J, Magerl M. New topics in bradykinin research.Allergy2011;66: 1397–1406. Abstract Bradykinin has been implicated to contribute to allergic inflammation and the pathogenesis of allergic conditions. It binds to endothelial B1and B2receptors and exerts potent pharmacological and physiological effects, notably, decreased blood pressure, increased vascular permeability and the promotion of classical symptoms of inflammation such as vasodilation, hyperthermia, oedema and pain. Towards potential clinical benefit, bradykinin has also been shown to exert potent antithrombogenic, antiproliferative and antifibrogenic effects. The development of pharmacologically active substances, such as bradykinin receptor blockers, opens up new therapeutic options that require further research into bradykinin. This review presents current understanding surrounding the role of bradykinin in nonallergic angioedema and other conditions seen by allergists and emergency physicians, and its potential role as a therapeutic target.
Source: Allergy
Institutions: Stiftung Charité, Charité – Universitätsmedizin Berlin, Max Delbrück Center, TUM Klinikum, Technical University of Munich, University of Trieste, University of Milan, Luigi Sacco Hospital, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Southampton, Medical University of South Carolina, Düsseldorf University Hospital, Lund University, University of Gothenburg
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: Shire Human Genetic Therapies
OpenAlex ID: W1942364642