Work

Amino acid metabolism in tumour-bearing mice

Year: 1988

Type: article

Abstract: Mice bearing the Lewis lung carcinoma showed a high tumour glutaminase activity and significantly higher concentrations of most amino acids than in both the liver and the skeletal muscle of the host. Tumour tissue slices showed a marked preference for glutamine, especially for oxidation of its skeleton to CO2. It is proposed that the metabolism of this particular carcinoma is focused on amino acid degradation, glutamine being its preferred substrate.

Source: Biochemical Journal

DOI: 10.1042/bj2490443

Authors: S Rivera, J Azcón-Bieto, F J López-Soriano, M Miralpeix, J M Argilés

Institution: Universitat de Barcelona

Language: English

Topic: Amino Acid Enzymes and Metabolism

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1944722283