Work

The human T-cell leukemia virus type 1 posttranscriptional trans-activator Rex contains a nuclear export signal

Year: 1996

Type: article

Abstract: The Rex protein of human T-cell leukemia virus type 1 is required for the nuclear export of unspliced viral mRNA and, therefore, for virus replication. In this manuscript, we demonstrate that Rex shuttles between the nucleus and the cytoplasm and that its activation domain constitutes a nuclear export signal that specifies efficient transport to the cytoplasm. These findings are consistent with a model for Rex-mediated trans-activation in which Rex-viral mRNA complexes are targeted for nuclear export by the direct action of the activation domain.

Source: Journal of Virology

DOI: 10.1128/jvi.70.9.6442-6445.1996

Authors: D Palmeri, M H Malim

Institution: University of Pennsylvania

Language: English

Topic: T-cell and Retrovirus Studies

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

Funder: National Human Genome Research Institute

Awards: MINORITY PREDOCTORAL FELLOWSHIP PROGRAM--NIGMS, G8017782386