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Nicotine Ameliorates Emotional and Cognitive Impairments Induced by Neonatal PolyI:C Treatment in Mice~!2009-12-18~!2010-07-05~!2010-09-09~!

Year: 2010
Type: article
Abstract: Environmental factors such as maternal and neonatal infection are potentially associated with the pathogenesis of various psychiatric disorders, including schizophrenia.Polyriboinosinic-polyribocytidilic acid (polyI:C) is a synthetic analogue of double-stranded RNA that induces strong innate immune responses.We have recently developed the mouse model of neurodevelopmental psychiatry disorders that exhibits emotional and cognitive impairments in adulthood following neonatal polyI:C treatment.In this study, we examined whether nicotine ameliorates emotional and cognitive impairments in the neonatal polyI:C model because recent studies have indicated the therapeutic benefits of nicotine in schizophrenia.Neonatal ICR mice were repeatedly injected with polyI:C (5 mg/kg, s.c.) for 5 days (postnatal days 2 to 6).At postnatal 10 weeks, emotional functions were analyzed in open field and social interaction tests.Cognitive function was analyzed in novel object recognition and prepulse inhibition (PPI) tests.PolyI:C-treated mice showed an increase in anxiety-like behaviors and impairments in social behaviors, object recognition memory, and PPI, compared with the vehicle-treated control group.Nicotine (0.15 and 0.5 mg/kg, s.c.) dose-dependently improved polyI:C-induced impairments of emotional and cognitive behaviors, but had no effect on PPI deficit.The ameliorating effect of nicotine was antagonized by pretreatment with dihydro-β-erythroidine or methyllycaconitine.These results suggest that nicotine ameliorates emotional and cognitive impairments of the present polyI:C model through nicotinic acetylcholine receptors.
DOI: 10.2174/1874230001004010009
Author: Jinghua Yu
Language: English
Open Access status: bronze
OpenAlex ID: W2319505496
FWCI: 0.225
Cites: 50
Cited by: 6
Related to: 10