Work

Hepatocellular carcinoma in patients listed for liver transplantation: Current and future allocation policy and management strategies for the individual patient

Year: 2015

Type: review

Abstract: Liver transplantation can provide definitive cure for patients with cirrhosis and hepatocellular carcinoma (HCC) when used appropriately. Advances in the management of HCC have allowed improved control of HCC while waiting for liver transplantation and new approaches to candidate selection particularly with regard to tumor burden and downstaging protocols. Additionally, there have been recent changes in allocation policy related to HCC in the U.S. that cap the HCC MELD exception at 34 points and implement a 6-month delay in a HCC MELD exception. This review examines the U.S. liver transplant allocation policy related to HCC, comprehensively details locoregional therapy options in HCC patients awaiting liver transplantation, and considers the impact of an increasing burden of HCC on future liver graft allocation policy.

Source: Liver Transplantation

DOI: 10.1002/lt.24356

Authors: Joel P. Wedd, Eric Nordstrom, Trevor Nydam, Janette Durham, Michael Zimmerman, Thor Johnson, W. Thomas Purcell, Scott W. Biggins

Institutions: Emory University, University of Colorado Anschutz, Medical College of Wisconsin

Language: English

Topic: Hepatocellular Carcinoma Treatment and Prognosis

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1947664836

FWCI: 0.623

Cites: 79

Cited by: 32

Related to: 10