Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients
Year: 2015
Type: article
Study design: Observational Study
Abstract: Here we perform the first genome-wide association study (GWAS) of multiple myeloma (MM) survival. In a meta-analysis of 306 MM patients treated at UCSF and 239 patients treated at the Mayo clinic, we find a significant association between SNPs near the gene FOPNL on chromosome 16p13 and survival (rs72773978; P=6 × 10−10). Patients with the minor allele are at increased risk for mortality (HR: 2.65; 95% CI: 1.94–3.58) relative to patients homozygous for the major allele. We replicate the association in the IMMEnSE cohort including 772 patients, and a University of Utah cohort including 318 patients (rs72773978 P=0.044). Using publicly available data, we find that the minor allele was associated with increased expression of FOPNL and increased expression of FOPNL was associated with higher expression of centrosomal genes and with shorter survival. Polymorphisms at the FOPNL locus are associated with survival among MM patients. Multiple myeloma is an incurable blood cancer with family history being a strong contributing risk factor. Here Ziv et al.perform a genome-wide association study for genetic variation associated with myeloma survival, identifying FOPNL variants associated with worse clinical outcomes.
Source: Nature Communications
DOI: 10.1038/ncomms8539
Authors: Elad Ziv, Eric Dean, Donglei Hu, Alessandro Martino, Daniel Serie, Karen Curtin, Daniele Campa, Blake Aftab, Paige Bracci, Gabriele Buda, Yi Zhao, Jennifer Caswell-Jin, Robert Diasio, Charles Dumontet, Marek Dudziński, Laura Fejerman, Alexandra Greenberg, Scott Huntsman, Krzysztof Jamroziak, Artur Jurczyszyn, Shaji Kumar, Djordje Atanackovic, Martha Glenn, Lisa A. Cannon-Albright, Brandt Jones, Adam Lee, Herlander Marques, Thomas Martin, Joaquin Martinez-Lopez, Vincent Rajkumar, Juan Sainz, Annette Juul Vangsted, Marzena Wątek, Jeffrey Wolf, Susan Slager, Nicola J. Camp, Federico Canzian, Celine Vachon
Institutions: University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center, Sutter Medical Center, Sutter Santa Rosa Regional Hospital, German Cancer Research Center, Mayo Clinic, Mayo Clinic in Florida, University of Utah, Azienda Ospedaliera Universitaria Pisana, Lyon 1 Université, Centre National de la Recherche Scientifique, Inserm, Centre de Recherche en Cancérologie de Lyon, Medical University of Lodz, Szpital Uniwersytecki w Krakowie, University of Minho, Universidad Complutense de Madrid, Hospital Universitario 12 De Octubre, Universidad de Granada, Hospital Universitario Virgen de las Nieves, Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research, University of Copenhagen, Roskilde Sygehus, Rigshospitalet, Holy Cross University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $6,990
OpenAlex ID: W1951009334