HbA1c in Patients with Polycystic Ovary Syndrome: A Potential Marker of Inflammation.
Year: 2015
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that is associated with increased inflammation, insulin resistance, and elevated risk of metabolic complications. hs-CRP is the most reliable marker of inflammation in PCOS patients. When hs-CRP is elevated, it can indicate increased risk of cardiovascular disease. The purpose of the study was to determine if a certain value of HbA1c in PCOS patients should alert clinicians to increased inflammation (as defined by hs-CRP >2 mg/l), thus potentially be indicative of increased risk of cardiovascular disease. METHODS: A cohort study was conducted on female patients between the ages of 20 to 45 years who fulfilled the National Institute of Health criteria for PCOS. De-identified data of 46 patients with PCOS were obtained. All clinical tests were conducted after a 12 hr overnight fast. hs-CRP was measured by latex-enhanced immunonephelometry. Logistic regression analysis was conducted to assess the association between hs-CRP and HbA1c. RESULTS: When various HbA1c levels were considered, a cutoff of 5.3% correctly classified patients with hs-CRP >2 mg/l at 80.4%. Sensitivity was 83.3% and specificity was 75%. CONCLUSION: An HbA1c cut off of 5.3% may be appropriate to initiate efforts for early detection of increased inflammation as a potential sign of risk for cardiovascular disease.
Source: Europe PMC (PubMed Central)
Authors: Rami Mortada, Ken James Kallail, Frank Dong, Sidika Karakas
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1951096798