Work

Dendritic nanoconjugates for intracellular delivery of neutral oligonucleotides

Year: 2015

Type: article

Abstract: Dendrimer-based gene delivery has been constrained by intrinsic toxicity and suboptimal nanostructure. Conjugation of neutral morpholino oligonucleotides (ONs) with PAMAM dendrimers resulted in neutral, uniform, and ultra-small (∼10 nm) nanoconjugates. The nanoconjugates dramatically enhanced cellular delivery of the ONs in cancer cells. After release from the dendrimer in the cytosol, the ONs produced potent functional activity without causing significant cytotoxicity. When carrying an apoptosis-promoting ON, the nanoconjugates produced cancer cell killing directly. Thus, the dendritic nanoconjugates may provide an effective tool for delivering ONs to tumors and other diseased tissues.

Source: Nanoscale

DOI: 10.1039/c5nr01665g

Authors: Xin Ming, Lin Wu, Kyle Carver, Ahu Yuan, Yuanzeng Min

Institutions: University of North Carolina at Chapel Hill, Jiangsu Province Hospital, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, UNC Lineberger Comprehensive Cancer Center

Language: English

Topic: Dendrimers and Hyperbranched Polymers

Subfield: Polymers and Plastics

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: China Scholarship Council, Akershus Universitetssykehus, National Institutes of Health, National Cancer Institute