The Acute Respiratory Distress Syndrome: From Mechanism to Translation
Year: 2015
Type: review
Abstract: The acute respiratory distress syndrome (ARDS) is a form of severe hypoxemic respiratory failure that is characterized by inflammatory injury to the alveolar capillary barrier, with extravasation of protein-rich edema fluid into the airspace. Although many modalities to treat ARDS have been investigated over the past several decades, supportive therapies remain the mainstay of treatment. In this article, we briefly review the definition, epidemiology, and pathophysiology of ARDS and present emerging aspects of ARDS pathophysiology that encompass modulators of the innate immune response, damage signals, and aberrant proteolysis that may serve as a foundation for future therapeutic targets.
Source: The Journal of Immunology
Authors: SeungHye Han, Rama K Mallampalli
Institutions: University of Pittsburgh, VA Pittsburgh Healthcare System
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Regulation of the interferon lamda receptor by influenza, Stabilizing mitochondria in sepsis, G7209639321, A New Genus of Ubiquitin-Based Anti-inflammatories for COPD, Immunosuppression in Acute Lung Injury, Sepsis-Associated Immune Suppression and F-box Proteins, E3 Ligase-Mediated Immunosuppression in Acute Lung Injury
OpenAlex ID: W1951409959