Pathophysiological basis of combination of radiotherapy and therapy directed to EGFR inhibition
Year: 2010
Type: article
Abstract: Radiotherapy plays an import ant role in the treatment of cancer patients. Frequently failure of the treatment (locoregional progression) is observed. Overactivity of EGFR-depentent intracellular signaling contributes to tumor progression and radioresistance. Therapeutic strategies aimed at inhibition EGFR activity are an attractive perspective in terms of increasing radiosensitivity of neoplastic cells. Numerous experimental studies allowed for identification of several mechanisms underlying local tumor control after combina
Source: Via Medica Journals
Authors: Ewa Sierko, Marek Z. Wojtukiewicz
Language: English
Topic: HER2/EGFR in Cancer Research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1953735467