Multiple Protein-Binding Sites in the 5′-Flanking Region Regulate c-fos Expression
Year: 1986
Type: article
Abstract: We tested sequences flanking the mouse c-fos gene for the ability to form specific DNA-protein complexes with factors present in crude nuclear extracts prepared from mammalian cells. Three such complexes were detected. One complex formed in a region necessary for the induction of c-fos expression by serum growth factors. Two additional complexes formed at sequences that contribute to basal c-fos promoter activity in vivo. These complexes represent three novel sequence-specific DNA-binding activities which appear to participate in the regulation of c-fos transcription.
Source: Molecular and Cellular Biology
Authors: M Z Gilman, R N Wilson, R A Weinberg
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: National Cancer Institute
Awards: G3114723080, G7510575383
OpenAlex ID: W1954580706