The circular relationship between matrix metalloproteinase‐9 and inflammation following myocardial infarction
Year: 2015
Type: article
Abstract: Matrix metalloproteinase-9 (MMP-9) regulates remodeling of the left ventricle after myocardial infarction (MI) and is tightly linked to the inflammatory response. The inflammatory response serves to recruit leukocytes as part of the wound healing reaction to the MI injury, and infiltrated leukocytes produce cytokines and chemokines that stimulate MMP-9 production and release. In turn, MMP-9 proteolyzes cytokines and chemokines. Although in most cases, MMP-9 cleavage of the cytokine or chemokine substrate serves to increase activity, there are cases where cleavage results in reduced activity. Global MMP-9 deletion in mouse MI models has proven beneficial, suggesting inhibition of some aspects of MMP-9 activity may be valuable for clinical use. At the same time, overexpression of MMP-9 in macrophages has also proven beneficial, indicating that we still do not fully understand the complexity of MMP-9 mechanisms of action. In this review, we summarize the cycle of MMP-9 effects on cytokine production and cleavage to regulate leukocyte functions. Although we use MI as the example process, similar events occur in other inflammatory and wound healing conditions.
Source: IUBMB Life
DOI: 10.1002/iub.1408
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze
Awards: G117204881, G1277891375, G1336385654, G182294559, G199696075, G2169460107, G2281790343, G2501379408, G2522261593, Systems Biology of Macrophage Polarizaiton Following Myocardial Infarction, G2962370141, G4086130786, G4386296807, A Community Effort to Translate Protein Data to Knowledge: An Integrated Platform, G4922965983, G5286880059, G5497377074, Cardiovascular Dynamics & Their Control, G6408202313, G7480745220, G752354275, Cardiorenal and Metabolic Diseases Research Center, G792079044, G8050617282, G9000009558, G9000055609, G9000156213, G9000266271
OpenAlex ID: W1956720104