Year: 2015
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: The nonlesioned motor cortex (M1NL) is thought to be hyperexcitable in patients with subacute or chronic stroke and offers a promising therapeutic target. However, whether M1NL excitability behaves the same for subcortical and cortical strokes is unknown. The aim of the present study was to determine whether cortical, or purely subcortical, strokes have a different effect on M1NL excitability. METHODS: We looked for correlations between the Fugl-Meyer (FM) score and M1NL resting motor threshold (RMTNL) in 34 stroke survivors classified according to lesion location (cortico-subcortical or purely subcortical). In addition to the FM, the Wolf Motor Score and motor power were measured. RESULTS: FM correlated with RMTNL for subcortical (r = 0.82; p = 0.001) but not for cortical strokes (r = 0.11; p = 0.62). Likewise, Wolf Motor Score (r = -0.62; p = 0.03) and motor power (r = 0.64; p = 0.023) were correlated with RMTNL for the subcortical group, but not for the cortical group. CONCLUSION: We show that the impact on M1NL depends on lesion location and conclude that protocols aimed at reducing M1NL cortical excitability may be worth exploring for subcortical but not for cortical stroke.
Source: Neurology
Institutions: University of Maryland, Baltimore, Beth Israel Deaconess Medical Center, Feinstein Institute for Medical Research, Harvard University, Fujita Health University, Cornell University, Spaulding Rehabilitation Hospital, Burke Medical Research Institute, Berenson Allen Center for Noninvasive Brain Stimulation, Weill Cornell Medicine, Massachusetts Institute of Technology, Newcastle University
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
Funders: Foundation for the National Institutes of Health, Sidney R. Baer, Jr. Foundation, Harvard University, Harvard Catalyst, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Center for Research Resources, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1087526407, Cortical connectivity, physiology, and response to stimulation in human epilepsy, Role of functional brain connectivity on efficacy of TMS for depression, Harvard Clinical and Translational Science Center (UL1), Cortical plasticity in type II diabetes mellitus, Transcranial Direct Current Stimulation and Robotic Training in Chronic Stroke, Transcranial Stimulation in Spino-Cerebellar Ataxia
OpenAlex ID: W1957158991