Year: 1970
Type: article
Study design: Case Report
Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) was diagnosed in a 26-year-old Nigerian woman who subsequently died of amebic colitis. The patient’s red cells exhibited mosaicism with respect to glucose 6-phosphate dehydrogenase, in that some of them had the A, and some of them had the B variant of this enzyme (as expected in female subjects heterozygous at this sex-linked locus). The red cells bearing the PNH abnormality only had the B variant, suggesting that they all belonged to a single abnormal clone.
Source: Blood
Authors: S. B. ONI, B. O. OSUNKOYA, L. LUZZATTO
Institution: University College Hospital, Ibadan
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1957167758