Work

Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection

Year: 1989

Type: article

Abstract: A mouse model of pneumonia caused by murine Chlamydia trachomatis (mouse pneumonitis agent) was used to demonstrate that whole spleen cells from both nude athymic mice (nu/nu) and heterozygous mice (nu/+) produced tumor necrosis factor alpha in vitro in response to mouse pneumonitis agent antigen. The tumor necrosis factor alpha measured in these supernatants by immunoassay was shown to have bioactivity in a cytotoxic assay in which uninfected target cells were used. This cytotoxicity was distinct from the gamma interferon-related cytotoxicity against C. trachomatis-infected targets that we described previously.

Source: Infection and Immunity

DOI: 10.1128/iai.57.5.1351-1355.1989

Authors: D M Williams, L F Bonewald, G D Roodman, G I Byrne, D M Magee, J Schachter

Institution: Audie L. Murphy Memorial VA Hospital

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases