Work

Up-regulation of D3 dopamine receptor mRNA in the nucleus accumbens of human cocaine fatalities

Year: 1997

Type: article

Abstract: The effects of chronic cocaine use on D3 receptor mRNA expression in the human nucleus accumbens was assessed by reverse transcription-polymerase chain reaction. D3 receptor/cyclophilin mRNA ratios in the nucleus accumbens were increased 6-fold in cocaine overdose victims as compared to age-matched and drug-free control subjects. This finding demonstrates that chronic cocaine exposure leads to adaptive increases in the expression of D3 receptor mRNA in a critical reward center in brain.

Source: Molecular Brain Research

DOI: 10.1016/s0169-328x(97)00025-9

Authors: David M Segal, Carlos T Moraes, Deborah C Mash

Institution: University of Miami

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute on Drug Abuse