Fast Production of Highly Reactive No‐Carrier‐Added [18F]Fluoride for the Labeling of Radiopharmaceuticals
Year: 2010
Type: article
Abstract: Doing without water: The 18F labeling of radiopharmaceuticals requires nearly anhydrous solutions of [18F]fluoride. Aqueous K2CO3 is generally used to elute [18F]fluoride from an anion-exchange resin. Replacing aqueous K2CO3 with strong organic bases, such as the phosphazene base P2Et (conjugate acid shown), enabled the recovery of highly reactive [18F]fluoride and avoided the azeotropic evaporation of water, which is very difficult on a microchip device.
Authors: Christian F. Lemaire, Joël J. Aerts, Samuel Voccia, Lionel C. Libert, Frédéric Mercier, David Goblet, Alain R. Plenevaux, André J. Luxen
Institution: University of Liège
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1963566581