Year: 1967
Type: article
Abstract: MEDIBCAILIJUNAL residual follicle stimulating hormone secretion leading to the production of polycystic ovaries (Ferriman, 1960) ; all follicle stimulating hormone secretion may have disappeared in the more severely affected patients.The development of sensitive and precise radio-immunological assays for gonadotrophins may shed some light on the problem before long.The incidence of conception in our series (9 out of 41) is higher than we would have anticipated from our previous experiences in the field.This has been the experience of many other workers (Greenblatt, 1966).It is not possible to make a precise statistical assessment of the comparative value of this drug in the absence of control data.The provision of such data would be of great interest.It is odd that while patients with polycystic ovaries show a better ovulatory response to clomiphene than those with normal- sized ovaries their conception rate should be lower.Perhaps the thickened capsules of the polycystic ovaries interfere with the release of ova, or the increased production of androgen by these ovaries impairs nidation. SummaryThe ovulatory response to clomiphene is significantly better in patients with menstrual cycles of less than six months' dura- tion compared with those whose cycles exceed this figure, and in patients with polycystic ovaries compared with those whose ovaries are of normal size.It is better in patients with basal oestrogen excretions exceeding 21 ,ug./24hours than in those whose excretion levels fall below this figure (obtained by a method having a nonspecific background fluorescence of 10 xug./24 hours), though the difference does not quite reach formal significance.Patients with normal-sized ovaries conceive more readily than those with polycystic ovaries.The difference does not quite reach formal significance.We wish to thank Dr. D.
Source: BMJ
Institution: Tel Aviv University
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1963595907