Work

Biochemical safety profiles of gadolinium‐based extracellular contrast agents and nephrogenic systemic fibrosis

Year: 2007

Type: review

Abstract: Gadolinium (Gd)-based paramagnetic contrast agents are relatively safe when used in clinically recommended doses. However, with the rapidly expanding body of literature linking Gd-based paramagnetic contrast agents and nephrogenic systemic fibrosis (NSF), awareness of the potential side effects and adverse reactions from Gd is now an important requirement for practicing radiologists. In addition to the ongoing accumulation and analyses of clinical NSF data, it is also essential for the practicing radiologist to understand the biochemical characteristics of the extracellular Gd-chelates. The purpose of this review is to consolidate and update the available information on known side effects, adverse reactions, and toxicity of the Gd chelates, with particular emphasis on the potential mechanisms of NSF.

Source: Journal of Magnetic Resonance Imaging

DOI: 10.1002/jmri.21135

Authors: Hale Ersoy, Frank J. Rybicki

Institutions: Brigham and Women's Hospital, Harvard University

Language: English

Topic: Lanthanide and Transition Metal Complexes

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Biomedical Imaging and Bioengineering