Work

CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics

Year: 2008

Type: article

Abstract: Aptamers, single stranded DNA or RNA molecules, generated by a method called SELEX (systematic evolution of ligands by exponential enrichment) have been widely used in various biomedical applications. The newly developed Cell-SELEX (cell based-SELEX) targeting whole living cells has raised great expectations for cancer biology, -therapy and regenerative medicine. Combining nanobiotechnology with aptamers, this technology opens the way to more sophisticated applications in molecular diagnosis. This paper gives a review of recent developments in SELEX technologies and new applications of aptamers.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms9040668

Authors: Ke-Tai Guo, Gerhard Ziemer, Angela Paul, Hans P. Wendel

Institution: Universitätsklinikum Tübingen

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499