Statin Use and Decline in Gait Speed in Community‐Dwelling Older Adults
Year: 2014
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: To examine the association between statin use and objectively assessed decline in gait speed in community-dwelling older adults. DESIGN: Longitudinal cohort study. SETTING: Health, Aging and Body Composition (Health ABC) Study. PARTICIPANTS: Two thousand five participants aged 70-79 at baseline with medication and gait speed data at 1998-99, 1999-2000, 2001-02, and 2002-03. MEASUREMENTS: The independent variables were any statin use and their standardized daily doses (low, moderate, high) and lipophilicity. The primary outcome measure was decline in gait speed of 0.1 m/s or more in the following year of statin use. Multivariable generalized estimating equations were used, adjusting for demographic characteristics, health-related behaviors, health status, and access to health care. RESULTS: Statin use increased from 16.2% in 1998-99 to 25.6% in 2002-03. The overall proportions of those with decline in gait speed of 0.1 m/s or more increased from 22.2% in 1998 to 23.9% in 2003. Statin use was not associated with decline in gait speed of 0.1 m/s or more (adjusted odds ratio (AOR) = 0.90, 95% confidence interval (CI) = 0.77-1.06). Similar nonsignificant trends were also seen with the use of hydrophilic or lipophilic statins. Users of low-dose statins were found to have a 22% lower risk of decline in gait speed than nonusers (AOR = 0.78, 95% CI = 0.61-0.99), which was mainly driven by the results from 1999-2000 follow-up. CONCLUSION: These results suggest that statin use did not increase decline in gait speed in community-dwelling older adults.
DOI: 10.1111/jgs.13134
Authors: Wei‐Hsuan Lo‐Ciganic, Subashan Perera, Shelly L. Gray, Robert M. Boudreau, Janice C. Zgibor, Elsa S. Strotmeyer, Julie M. Donohue, Clareann H. Bunker, Anne B. Newman, Eleanor M. Simonsick, Douglas C. Bauer, Suzanne Satterfield, Paolo Caserotti, Tamara Harris, Ronald I. Shorr, Joseph T. Hanlon, the Health, Aging and Body Composition Study
Institutions: University of Pittsburgh, University of Washington, National Institute on Aging, University of California, San Francisco, University of Tennessee Health Science Center, University of Southern Denmark, North Florida/South Georgia Veterans Health System, Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G100949702, DYNAMICS OF HEALTH,AGING, AND BODY COMPOSITION, Peripheral nerve decline: an underappreciated cause of injurious falls, Longitudinal Impact of Antihypertensive Polypharmacy on Geriatric Syndromes, DYNAMICS OF HEALTH, AGING, AND BODY COMPOSITION, Intervention to Reduce Dietary Sodium in Hemodialysis, IMPACT OF MEDICARE PART D ON RACIAL DISPARITIES IN DIABETES TREATMENT AND OUTCOME, G2741792843, HEALTH ABC--COORDINATING UNIT, G405217353, G405715915, G5743784024, G5909482378, G640327682, End of Life in the Very Old, G670738241, G692659954, G710829228, ENHANCING THE DETECTION AND MANAGEMENT OF ADVERSE DRUG EVENTS IN THE NURSING HOME, UPITT Program for Pharmaceutical Outcomes Research in Aging, G861947890, G870807107, G88327988, Pittsburgh Older Americans Independence Center, G945304896
OpenAlex ID: W1963728050