Work

Cytoplasmic dynein and dynactin in cell division and intracellular transport

Year: 1999

Type: review

Abstract: Since the initial discovery of cytoplasmic dynein, it has become apparent that this microtubule-based motor is involved in several cellular functions including cell division and intracellular transport. Another multisubunit complex, dynactin, may be required for most, if not all, cytoplasmic dynein-driven activities and may provide clues to dynein's functional diversity. Recent genetic and biochemical findings have illuminated the cellular roles of dynein and dynactin and provided insight into the functional mechanism of this complex motor.

Source: Current Opinion in Cell Biology

DOI: 10.1016/s0955-0674(99)80006-4

Authors: Sher Karki, Erika LF Holzbaur

Institution: University of Pennsylvania

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,390

OpenAlex ID: W1963851313

FWCI: 3.327

Cites: 97

Cited by: 458

Related to: 10