Work

Subcellular mRNA Localization in Animal Cells and Why It Matters

Year: 2009

Type: review

Abstract: Subcellular localization of messenger RNAs (mRNAs) can give precise control over where protein products are synthesized and operate. However, just 10 years ago many in the broader cell biology community would have considered this a specialized mechanism restricted to a very small fraction of transcripts. Since then, it has become clear that subcellular targeting of mRNAs is prevalent, and there is mounting evidence for central roles for this process in many cellular events. Here, we review current knowledge of the mechanisms and functions of mRNA localization in animal cells.

Source: Science

DOI: 10.1126/science.1176488

Authors: Christine E. Holt, Simon L. Bullock

Institutions: University of Cambridge, MRC Laboratory of Molecular Biology, Medical Research Council

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: Wellcome Trust

Award: Axon navigation in the developing brain.