Work

Truncated glucagon‐like peptide I, an insulin‐releasing hormone from the distal gut

Year: 1987

Type: article

Abstract: By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78-107 as suggested by chromatography and determination of its N-terminal sequence. Natural and synthetic proglucagon 78-107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78-107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.

Source: FEBS Letters

DOI: 10.1016/0014-5793(87)81430-8

Authors: J.J. Holst, C. Ørskov, O. Vagn Nielsen, T.W. Schwartz

Institutions: University of Copenhagen, Rigshospitalet

Language: English

Topic: Pancreatic function and diabetes

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1964212912

FWCI: 12.44

Cites: 19

Cited by: 624

Related to: 10