Work

Evidence for Extrinsic Exonucleolytic Proofreading

Year: 2006

Type: article

Abstract: Exonucleolytic proofreading of DNA synthesis errors is one of the major determinants of genome stability. However, many DNA transactions that contribute to genome stability require synthesis by polymerases that naturally lack intrinsic 3' exonuclease activity and some of which are highly inaccurate. Here we discuss evidence that errors made by these polymerases may be edited by a separate 3' exonuclease, and we consider how such extrinsic proofreading may differ from proofreading by exonucleases that are intrinsic to replicative DNA polymerases.

Source: Cell Cycle

DOI: 10.4161/cc.5.9.2736

Authors: Stephanie A. Nick McElhinny, Youri I. Pavlov, Thomas A. Kunkel

Institutions: United States Department of Health and Human Services, National Institutes of Health, National Institute of Environmental Health Sciences

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: University of Nebraska Medical Center, National Institutes of Health, National Institute of Environmental Health Sciences, NHLBI Division of Intramural Research

Award: Structure-Function Studies Of DNA Replication Fidelity