Work

Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia

Year: 2006

Type: article

Study design: Observational Study

Abstract: The transcription factor CEBPA is crucial for normal myeloid differentiation. CEBPA gene mutations have been reported in patients with acute myeloid leukaemia. The inevitable evolution of chronic myeloid leukaemia (CML) in chronic phase (CP) to a fatal blast crisis (BC) is assumed to result from the acquisition of additional genetic changes in the leukaemic clone. Gain of CEBPA mutations might represent a key event causing the differentiation block observed in myeloid CML-BC, but not in CML-CP. Here, no CEBPA mutation in 95 CML-BC patients was found, suggesting a limited role, if any, of CEBPA mutations in this disorder.

Source: British Journal of Haematology

DOI: 10.1111/j.1365-2141.2006.06057.x

Authors: Thomas Pabst, Erica Stillner, Donna Neuberg, Stephen Nimer, Cheryl L. Willman, Alan F. List, Junia V. Melo, Daniel G. Tenen, Beatrice U. Mueller

Institutions: University Hospital of Bern, Harvard University, Dana-Farber Cancer Institute, Memorial Sloan Kettering Cancer Center, University of New Mexico, Moffitt Cancer Center, Hammersmith Hospital, Imperial College London

Language: English

Topic: Chronic Myeloid Leukemia Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Science Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Awards: The block in differentiation in CBF leukemias is caused by suppression of the myeloid key transcription factor CEBPA, mediated by activation of Calreticulin, The transcription factor PU.1 is essential for normal hematopoiesis: Analyses of PU.1 alterations in patients with acute leukemia, G8832621192

OpenAlex ID: W1964343586

FWCI: 1.801

Cites: 12

Cited by: 17

Related to: 10