Work

Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF

Year: 2009

Type: review

Abstract: Bone is a highly vascularized tissue, but the function of angiogenesis in bone modeling and remodeling is still poorly defined, and the molecular mechanisms that regulate angiogenesis in bone are only partially elucidated. Genetic manipulations in mice have recently highlighted the critical role of the hypoxia-inducible-factor/vascular endothelial growth factor pathway in coupling angiogenesis and osteogenesis. In this brief perspective, we review the current understanding of the mechanisms responsible for this coupling. Elucidation of such mechanisms will expand our knowledge of bone development and homeostasis, and it may aid in the design of new therapies for accelerating bone regeneration and repair.

Source: Journal of Bone and Mineral Research

DOI: 10.1359/jbmr.090602

Authors: Ernestina Schipani, Christa Maes, Geert Carmeliet, Gregg L Semenza

Institutions: Harvard University, Massachusetts General Hospital, KU Leuven

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases