Year: 2011
Type: article
Abstract: The Growth Hormone and Insulin-like Growth Factor-1 (IGF-1) axis plays a pivotal role in critical illness, with a derangement leading to profound changes in metabolism. Protein wasting with skeletal muscle loss, delayed wound healing, and impaired recovery of organ systems are some of the most feared consequences. The use of human recombinant Growth Hormone (rhGH) and Insulin-like Growth Factor-1 (IGF-1) - alone and in combination - has been studied extensively in preclinical and clinical trials. This article reviews the current knowlegde and clinical practice of the use of rhGh and IGF-1 in critically ill patients, with a special focus on the trauma and burns patient population.
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,450
Funders: Shriners Hospitals for Children, National Institutes of Health, National Institute on Disability and Rehabilitation Research, National Institute of General Medical Sciences, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1269216684, G1751703132, G1951137196, G2429864182, Modulation of the post-burn catabolic response by modification of androgen and glucocorticoid pathways, G2551726678, G2768246053, G2773829713, Oxandrolone and Exercise: A potent therapy in the rehabilitation from burns, UTMB Clinical and Translational Science Award, G4730625931, G5489593142, G5917887185, G7303800072, G754466968, G7566994939, UTMB Clinical and Translational Science Award, G843758178, G88069994, G9000048782, G9000082160, G9000311520
OpenAlex ID: W1964596966