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A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II

Year: 1989

Type: article

Abstract: A single point mutation of the rat sodium channel II reduces its sensitivity to tetrodotoxin and saxitoxin by more than three orders of magnitude. The mutation replaces glutamic acid 387 with a glutamine and has only slight effects on the macroscopic current properties, as measured under voltage-clamp in Xenopus oocytes injected with the corresponding cDNA-derived mRNA.

Source: FEBS Letters

DOI: 10.1016/0014-5793(89)81531-5

Authors: Masaharu Noda, Harukazu Suzuki, Shosaku Numa, Walter Stühmer

Institutions: Kyoto University, Max Planck Institute for Biophysical Chemistry

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: Japan Science and Technology Agency

OpenAlex ID: W1964606508

FWCI: 6.246

Cites: 33

Cited by: 344

Related to: 10