Work

Synthesis and Preliminary Biological Studies of 3-Substituted Indoles Accessed by a Palladium-Catalyzed Enantioselective Alkene Difunctionalization Reaction

Year: 2010

Type: article

Abstract: A unique alkene difunctionalization reaction that allows rapid construction of molecular complexity around the biologically relevant indole framework has been developed. The reaction proceeds with up to 87% yield, 99:1 er, and >20:1 dr. Evaluation of several of the compounds revealed promising anticancer activity against MCF-7 cells.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja103472a

Authors: Tejas P. Pathak, Keith M. Gligorich, Bryan E. Welm, Matthew S. Sigman

Institutions: University of Utah, Huntsman Cancer Institute

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of General Medical Sciences

Awards: G1843171240, Pd-Catalyzed Olefin Functionalization Reactions for Organic Synthesis, Identification of Novel Cancer Selective Compounds in 3D Tumor Organoid Assays