Apoptosis of stem cells likely determines the manifestation of type 2 diabetic nephropathy: predictive and preventive potentials
Year: 2014
Type: article
Abstract: Scientific objective One of the most pressing health-related challenges is the worldwide epidemic of type 2 diabetes and associated complications such as nephropathy. Indeed, type 2 diabetic patients account for the majority of individuals with chronic kidney disease requiring renal replacement therapy. This not only suggests inadequacy of current drug therapies but also failure of endogenous protective mechanisms. Stem cells are known to play pivotal roles in repair and regeneration of damaged/dysfunctional tissues. Our initial observations suggested that initiation and progression of type 2 diabetes mellitus is associated with progressive reduction in endothelial progenitor cells in the obese diabetic db/db mice. Thus, the present study was intended to more fully explore the status of components of stem cells in the setting of type 2 diabetic nephropathy and whether the diabetic milieu affects the survivability of these cells.
Source: The EPMA Journal
Institution: Augusta University
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,890
OpenAlex ID: W1964777412