Work

Cryptosporidium parvum Infection Requires Host Cell Actin Polymerization

Year: 2001

Type: article

Abstract: The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection.

Source: Infection and Immunity

DOI: 10.1128/iai.69.9.5940-5942.2001

Authors: David A. Elliott, Daniel J. Coleman, Michael A. Lane, Robin C. May, Laura M. Machesky, Douglas P. Clark

Institutions: Johns Hopkins University, Johns Hopkins Medicine, University of Birmingham

Language: English

Topic: Parasitic Infections and Diagnostics

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1964832261

FWCI: 5.904

Cites: 32

Cited by: 97

Related to: 10