Work

Yeast POL5 Is an Evolutionarily Conserved Regulator of rDNA Transcription Unrelated to Any Known DNA Polymerases

Year: 2003

Type: article

Abstract: We show that yeast protein Yel055cp, which has been identified as the fifth essential DNA polymerase in Saccharomyces cerevisiae (POL5), is a member of a family of predicted rDNA transcription regulators (typified by human MYB-binding protein MYBBP1 A), which are represented by a single ortholog in all animals, fungi and plants with sequenced genomes. These proteins are confidently predicted to have an entirely a-helical structure and are unrelated to the B class DNA polymerases, as claimed for yeast POL5, or any other known polymerases.

Source: Cell Cycle

DOI: 10.4161/cc.2.2.329

Authors: Wei Yang, Igor B. Rogozin, Eugene V. Koonin

Institutions: National Institutes of Health, National Center for Biotechnology Information

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W1964850416

FWCI: 0.322

Cites: 17

Cited by: 14

Related to: 10