Work

Perspective: virus infections and the death of neurons

Year: 1999

Type: review

Abstract: Neuronotropic viruses induce apoptosis in neurons, and Bcl-2-related anti-apoptotic proteins and caspase inhibitors decrease mortality from acute viral encephalitis. Infected neurons develop cytoplasmic blebbing characteristic of apoptosis, but a paucity of apoptotic nuclear changes potentially indicates unique aspects of virus-induced neuronal apoptosis that remain to be discovered.

Source: Trends in Microbiology

DOI: 10.1016/s0966-842x(99)01470-5

Authors: Diane E Griffin, J.Marie Hardwick

Institution: Johns Hopkins University

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030