Work

The effect of antiretrovirals on Plasmodium falciparum liver stages

Year: 2013

Type: article

Abstract: HIV and malaria overlap geographically, but the full impact of different antiretrovirals on malaria remains poorly understood. We examined the antimalarial activity of the HIV protease inhibitors lopinavir and saquinavir and the non-nucleoside reverse transcriptase inhibitor nevirapine on Plasmodium falciparum liver stages. Our results demonstrate that the HIV PI lopinavir inhibits liver stage parasites at clinically relevant concentrations, that is, at drug levels achieved in HIV-infected patients on standard dosing regimens. Because drugs that inhibit liver stages target parasites when they are present in lower numbers, these results might have implications for eradication efforts.

Source: AIDS

DOI: 10.1097/qad.0b013e3283621dd4

Authors: Charlotte V. Hobbs, Patricia De La Vega, Scott R. Penzak, Jillian Van Vliet, Urszula Krzych, Photini Sinnis, William Borkowsky, Patrick E. Duffy

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Walter Reed Army Institute of Research, National Institutes of Health Clinical Center, Johns Hopkins University, New York University

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Defense, Agence Nationale de la Recherche, Vedecká Grantová Agentúra MŠVVaŠ SR a SAV, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: Structure and Function of the Circumsporozoite Protein, HIV Drugs and Their Impact on Malaria Infection and Immunity, G8838525055

OpenAlex ID: W1965091439

FWCI: 2.72

Cites: 16

Cited by: 18

Related to: 10