Work

A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells

Year: 2000

Type: article

Abstract: We previously have obtained operational evidence of a hematopoietic cell L-selectin ligand expressed on normal human hematopoietic cells and on leukemic blasts. Using a technique developed in our laboratory for analyzing and identifying adhesion molecules, we show here that hematopoietic cell L-selectin ligand is a specialized glycoform of CD44. This L-selectin ligand activity of CD44 requires sialofucosylated N-linked glycans and is sulfation-independent. These data provide important insights on the structural biology of CD44 and reveal a role for this protein as an L-selectin ligand on human hematopoietic cells.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.250484797

Authors: Charles J. Dimitroff, Jack Y. Lee, Robert C. Fuhlbrigge, Robert Sackstein

Institutions: Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute