Work

Effects of Prostaglandin Analogues on Aqueous Humor Outflow Pathways

Year: 2013

Type: review

Abstract: Elevated intraocular pressure (IOP) is the most prevalent risk factor for glaucoma. All treatments, whether surgical or pharmaceutical, are aimed at lowering IOP. Prostaglandin analogues are a first line therapy for glaucoma due to their ability to reduce IOP, once-daily dosing, efficacy, and minimal side-effect profile. Whereas prostaglandin analogues have been known to alter aqueous humor outflow through the unconventional (uveoscleral) pathway, more recent evidence suggests their action also occurs through the conventional (trabecular) pathway. Understanding how prostaglandin analogues successfully lower IOP is important, as this information may lead to the discovery of new molecular targets for future therapeutic intervention. This review explores the current understanding of prostaglandin analogue biology as it pertains to IOP reduction and improved aqueous humor outflow facility.

Source: Journal of Ocular Pharmacology and Therapeutics

DOI: 10.1089/jop.2013.0179

Authors: Nelson S. Winkler, Michael P. Fautsch

Institution: Mayo Clinic

Language: English

Topic: Glaucoma and retinal disorders

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Research to Prevent Blindness, Mayo Foundation for Medical Education and Research, National Institutes of Health, National Eye Institute