Development of Channeled Nanofibrous Scaffolds for Oriented Tissue Engineering
Year: 2012
Type: article
Abstract: A tissue-engineering scaffold resembling the structure of the natural extracellular matrix can often facilitate tissue regeneration. Nerve and tendon are oriented micro-scale tissue bundles. In this study, a method combining injection molding and thermally induced phase separation techniques is developed to create single- and multiple-channeled nanofibrous poly(L-lactic acid) scaffolds. The overall shape, the number and spatial arrangement of channels, the channel wall matrix architecture, the porosity and mechanical properties of the scaffolds are all tunable. The porous NF channel wall matrix provides an excellent microenvironment for protein adsorption and the attachment of PC12 neuronal cells and tendon fibroblast cells, showing potential for neural and tendon tissue regeneration.
Source: Macromolecular Bioscience
Authors: Chenghui Sun, Xiaobing Jin, Jeremy M. Holzwarth, Xiaohua Liu, Jiang Hu, Melanie J. Gupte, Yaoming Zhao, Peter X. Ma
Institutions: University of Michigan, South China University of Technology
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W1965405838